LY295427, A NOVEL HYPOCHOLESTEROLEMIC AGENT, ENHANCES [3H]25-HYDROXYCHOLESTEROL BINDING TO LIVER CYTOSOLIC PROTEINS

LY295427, a novel hypocholesterolemic agent, enhances [3H]25-hydroxycholesterol binding to liver cytosolic proteins

LY295427, (3 alpha,4 alpha,5 alpha)-4-(2-propenylcholestan-3-ol), acts through an unknown mechanism to derepress the transcription of the low density lipoprotein (LDL) receptor in the presence of 25-hydroxycholesterol (25-OH chol).Preincubation with LY295427 in Chinese hamster ovary (CHO) cells increased uptake of 25-OH chol in a time-dependent man

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Adjusting Group Intercept and Slope Bias in Predictive Equations

Methods to assess measurement invariance in constructs have received much attention, as invariance is critical for accurate group Shorts comparisons.Less attention has been given to the identification and correction of the sources of non-invariance in predictive equations.This work developed correction factors for structural intercept and slope bia

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Two effective cases of additional pedal artery angioplasty for severe lower limb ischemia following acute thrombotic artery occlusion with hypercoagulable state diseases

Abstract Background Acute limb ischemia (ALI) and A/C Adaptor critical limb ischemia (CLI) following ALI are life-threatening diseases.The rare potential causes of ALI include hypercoagulable state diseases, such as antiphospholipid syndrome (APS) and essential thrombocythemia (ET).Hypercoagulability often make revascularization for arterial occlus

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Enhanced hydrogen generation efficiency of methanol using dielectric barrier discharge plasma methodology and conducting sea water as an electrode

In this work, methanol decomposition method has been discussed for the production of hydrogen gas with the application of plasma.A simple dielectric Gloves barrier discharge (DBD) plasma reactor was designed for this purpose with two types of electrode.The DBD plasma reactor was experimented by substituting one of the metal electrodes with feebly c

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